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Possible mechanisms and function of nuclear trafficking of the colony-stimulating factor-1 receptor

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Abstract

Receptor tyrosine kinases (RTK) have long being studied with respect to the “canonical” signaling. This includes ligand-induced activation of a receptor tyrosine kinase at the cell surface that leads to receptor dimerization, followed by its phosphorylation in the intracellular domain and activation. The activated receptor then recruits cytoplasmic signaling molecules including other kinases. Activation of the downstream signaling cascade frequently leads to changes in gene expression following nuclear translocation of downstream targets. However, RTK themselves may localize within the nucleus, as either full-length molecules or cleaved fragments, with or without their ligands. Significant differences in this mechanism have been reported depending on the individual RTK, cellular context or disease. Accumulating evidences indicate that the colony-stimulating factor-1 receptor (CSF-1R) may localize within the nucleus. To date, however, little is known about the mechanism of CSF-1R nuclear shuttling, as well as the functional role of nuclear CSF-1R.

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Acknowledgments

This work was supported by Associazione Italiana per la Ricerca sul Cancro, Istituto Toscano Tumori, Ministero della Salute, Regione Toscana, Fondazione Cassa di Risparmio di Volterra, Fondazione Oretta Bartolomei-Corsi.

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Authors and Affiliations

  1. Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”, Sezione di Patologia e Oncologia Sperimentali, Istituto Toscano Tumori, Università degli Studi di Firenze, Viale G.B. Morgagni 50, 50134, Florence, Italy

    Elisabetta Rovida & Persio Dello Sbarba

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  1. Elisabetta Rovida
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  2. Persio Dello Sbarba
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Correspondence to Elisabetta Rovida.

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Rovida, E., Dello Sbarba, P. Possible mechanisms and function of nuclear trafficking of the colony-stimulating factor-1 receptor. Cell. Mol. Life Sci. 71, 3627–3631 (2014). https://doi.org/10.1007/s00018-014-1668-2

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