Cellular and Molecular Life Sciences

, Volume 71, Issue 14, pp 2699–2706

Gene–ethanol interactions underlying fetal alcohol spectrum disorders

Authors

  • Neil McCarthy
    • Molecular Biosciences, Waggoner Center for Alcohol and Addiction Research, Institute for Cellular and Molecular BiologyUniversity of Texas at Austin
    • Molecular Biosciences, Waggoner Center for Alcohol and Addiction Research, Institute for Cellular and Molecular BiologyUniversity of Texas at Austin
Review

DOI: 10.1007/s00018-014-1578-3

Cite this article as:
McCarthy, N. & Eberhart, J.K. Cell. Mol. Life Sci. (2014) 71: 2699. doi:10.1007/s00018-014-1578-3

Abstract

Fetal alcohol spectrum disorders (FASD) is an umbrella term that describes a diverse set of ethanol-induced defects. The phenotypic variation is generated by numerous factors, including timing and dosage of ethanol exposure as well as genetic background. We are beginning to learn about how the concentration, duration, and timing of ethanol exposure mediate variability within ethanol teratogenesis. However, little is known about the genetic susceptibilities in FASD. Studies of FASD animal models are beginning to implicate a number of susceptibility genes that are involved in various pathways. Here we review the current literature that focuses on the genetic predispositions in FASD.

Keywords

Fetal alcohol spectrum disordersFetal alcohol syndromeGene–environment interactionsGenetic predisposition

Copyright information

© Springer Basel 2014