Cellular and Molecular Life Sciences

, Volume 70, Issue 23, pp 4431–4448

Positive and negative influence of the matrix architecture on antitumor immune surveillance

  • Elisa Peranzoni
  • Ana Rivas-Caicedo
  • Houcine Bougherara
  • Hélène Salmon
  • Emmanuel Donnadieu
Review

DOI: 10.1007/s00018-013-1339-8

Cite this article as:
Peranzoni, E., Rivas-Caicedo, A., Bougherara, H. et al. Cell. Mol. Life Sci. (2013) 70: 4431. doi:10.1007/s00018-013-1339-8

Abstract

The migration of T cells and access to tumor antigens is of utmost importance for the induction of protective anti-tumor immunity. Once having entered a malignant site, T cells encounter a complex environment composed of non-tumor cells along with the extracellular matrix (ECM). It is now well accepted that a deregulated ECM favors tumor progression and metastasis. Recent progress in imaging technologies has also highlighted the impact of the matrix architecture found in solid tumor on immune cells and especially T cells. In this review, we argue that the ability of T cells to mount an antitumor response is dependent on the matrix structure, more precisely on the balance between pro-migratory reticular fiber networks and unfavorable migration zones composed of dense and aligned ECM structures. Thus, the matrix architecture, that has long been considered to merely provide the structural framework of connective tissues, can play a key role in facilitating or suppressing the antitumor immune surveillance. A new challenge in cancer therapy will be to develop approaches aimed at altering the architecture of the tumor stroma, rendering it more permissive to antitumor T cells.

Keywords

TumorT cellsStromaExtracellular matrixMotilityImaging

Abbreviations

3D

Three-dimensional

ECM

Extracellular matrix

EMT

Epithelial-mesenchymal transition

FRC

Fibroblastic reticular cells

LOX

Lysyl oxidase

LTi

Lymphoid tissue inducer

MMP

Metalloproteinases

SHG

Second-harmonic generation

SLO

Secondary lymphoid organs

TACS

Tumor-associated collagen signature

TIL

Tumor-infiltrating lymphocytes

TLO

Tertiary lymphoid organs

Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Elisa Peranzoni
    • 1
    • 2
    • 3
  • Ana Rivas-Caicedo
    • 4
  • Houcine Bougherara
    • 1
    • 2
    • 3
  • Hélène Salmon
    • 5
  • Emmanuel Donnadieu
    • 1
    • 2
    • 3
    • 6
  1. 1.Inserm, U1016, Institut CochinParisFrance
  2. 2.Cnrs UMR8104ParisFrance
  3. 3.Université Paris DescartesSorbonne Paris CitéFrance
  4. 4.Alta Tecnología en Laboratorios SA de CVMexicoMexico
  5. 5.Department of Oncological SciencesMount Sinai School of MedicineNew YorkUSA
  6. 6.Département d’Immunologie et d’HématologieInstitut CochinParisFrance