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Regulation of organogenesis and stem cell properties by T-box transcription factors

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Abstract

T-box transcription factors containing the common DNA-binding domain T-box contribute to the organization of multiple tissues in vertebrates and invertebrates. In mammals, 17 T-box genes are divided into five subfamilies depending on their amino acid homology. The proper distribution and expression of individual T-box transcription factors in different tissues enable regulation of the proliferation and differentiation of tissue-specific stem cells and progenitor cells in a suitable time schedule for tissue organization. Consequently, uncontrollable expressions of T-box genes induce abnormal tissue organization, and eventually cause various diseases with malformation and malfunction of tissues and organs. Furthermore, some T-box transcription factors are essential for maintaining embryonic stem cell pluripotency, improving the quality of induced pluripotent stem cells, and inducing cell-lineage conversion of differentiated cells. These lines of evidence indicate fundamental roles of T-box transcription factors in tissue organization and stem cell properties, and suggest that these transcription factors will be useful for developing therapeutic approaches in regenerative medicine.

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Acknowledgments

A.S. is funded by the Program for Improvement of the Research Environment for Young Researchers from the Special Coordination Funds for Promoting Science and Technology commissioned by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, a Grant-in-Aid for Scientific Research from the MEXT of Japan, a Health Labour Sciences Research Grant in Japan, the Core Research for Evolutional Science and Technology (CREST) Program of the Japan Science and Technology Agency, the Precursory Research for Embryonic Science and Technology (PRESTO) Program of the Japan Science and Technology Agency, The Uehara Memorial Foundation, The Takeda Science Foundation, and The Research Foundation for Pharmaceutical Sciences.

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  1. Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Yasuo Takashima & Atsushi Suzuki

  2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Atsushi Suzuki

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  1. Yasuo Takashima
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Correspondence to Atsushi Suzuki.

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Takashima, Y., Suzuki, A. Regulation of organogenesis and stem cell properties by T-box transcription factors. Cell. Mol. Life Sci. 70, 3929–3945 (2013). https://doi.org/10.1007/s00018-013-1305-5

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  • DOI: https://doi.org/10.1007/s00018-013-1305-5

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