Cellular and Molecular Life Sciences

, Volume 70, Issue 6, pp 1035–1053

Systems biology for molecular life sciences and its impact in biomedicine


DOI: 10.1007/s00018-012-1109-z

Cite this article as:
Medina, M.Á. Cell. Mol. Life Sci. (2013) 70: 1035. doi:10.1007/s00018-012-1109-z


Modern systems biology is already contributing to a radical transformation of molecular life sciences and biomedicine, and it is expected to have a real impact in the clinical setting in the next years. In this review, the emergence of systems biology is contextualized with a historic overview, and its present state is depicted. The present and expected future contribution of systems biology to the development of molecular medicine is underscored. Concerning the present situation, this review includes a reflection on the “inflation” of biological data and the urgent need for tools and procedures to make hidden information emerge. Descriptions of the impact of networks and models and the available resources and tools for applying them in systems biology approaches to molecular medicine are provided as well. The actual current impact of systems biology in molecular medicine is illustrated, reviewing two cases, namely, those of systems pharmacology and cancer systems biology. Finally, some of the expected contributions of systems biology to the immediate future of molecular medicine are commented.


ComplexityDisease-omeHolismNetworkReductionismSystems biology

Supplementary material

18_2012_1109_MOESM1_ESM.docx (51 kb)
Supplementary material 1 (DOCX 50 kb)

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Department of Molecular Biology and BiochemistryUniversity of MálagaMalagaSpain
  2. 2.CIBER de Enfermedades Raras (CIBERER)MálagaSpain
  3. 3.Departamento de Biología Molecular y Bioquímica, Facultad de CienciasUniversidad de MálagaMálagaSpain