Cellular and Molecular Life Sciences

, Volume 69, Issue 15, pp 2465–2468

PGC-1α: a master gene that is hard to master

  • Dan Lindholm
  • Ove Eriksson
  • Johanna Mäkelä
  • Natale Belluardo
  • Laura Korhonen
Visions and Reflections

DOI: 10.1007/s00018-012-1043-0

Cite this article as:
Lindholm, D., Eriksson, O., Mäkelä, J. et al. Cell. Mol. Life Sci. (2012) 69: 2465. doi:10.1007/s00018-012-1043-0

Abstract

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?

Keywords

PGC-1α Mitochondria Dopaminergic neurons Transgenic animal Adenovirus Parkinson’s disease 

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Dan Lindholm
    • 1
    • 2
  • Ove Eriksson
    • 1
    • 3
  • Johanna Mäkelä
    • 1
    • 2
  • Natale Belluardo
    • 4
  • Laura Korhonen
    • 1
    • 2
  1. 1.Institute of Biomedicine, Biochemistry and Developmental BiologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Minerva Medical Research InstituteHelsinkiFinland
  3. 3.Research Program Unit, Biomedicum Helsinki 1University of HelsinkiHelsinkiFinland
  4. 4.Division of Human Physiology, Department of Experimental Biomedicine and Clinical NeuroscienceUniversity of PalermoPalermoItaly