Cellular and Molecular Life Sciences

, Volume 69, Issue 20, pp 3395–3418

Type I IFN-mediated regulation of IL-1 production in inflammatory disorders

  • Kristina Ludigs
  • Valeriy Parfenov
  • Renaud A. Du Pasquier
  • Greta Guarda
Review

DOI: 10.1007/s00018-012-0989-2

Cite this article as:
Ludigs, K., Parfenov, V., Du Pasquier, R.A. et al. Cell. Mol. Life Sci. (2012) 69: 3395. doi:10.1007/s00018-012-0989-2

Abstract

Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral, malignant, and even inflammatory diseases. Interleukin-1 (IL-1) is a strongly pyrogenic cytokine and its importance in the development of several inflammatory diseases is clearly established. While the therapeutic use of IL-1 blocking agents is particularly successful in the treatment of innate-driven inflammatory disorders, IFN treatment has mostly been appreciated in the management of multiple sclerosis. Interestingly, type I IFNs exert multifaceted immunomodulatory effects, including the reduction of IL-1 production, an outcome that could contribute to its efficacy in the treatment of inflammatory diseases. In this review, we summarize the current knowledge on IL-1 and IFN effects in different inflammatory disorders, the influence of IFNs on IL-1 production, and discuss possible therapeutic avenues based on these observations.

Keywords

Type I IFNIL-1InflammasomeInflammatory disordersAutoimmunityMultiple sclerosisAnti-IL-1 therapy

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Kristina Ludigs
    • 1
  • Valeriy Parfenov
    • 2
  • Renaud A. Du Pasquier
    • 2
  • Greta Guarda
    • 1
  1. 1.Department of BiochemistryUniversity of LausanneEpalingesSwitzerland
  2. 2.Service of Neurology, Department of Clinical Neurosciences and Service of ImmunologyUniversity Hospital of LausanneLausanneSwitzerland