Cellular and Molecular Life Sciences

, Volume 69, Issue 16, pp 2635–2656

Regenerating functional heart tissue for myocardial repair

Review

DOI: 10.1007/s00018-012-0942-4

Cite this article as:
Alcon, A., Cagavi Bozkulak, E. & Qyang, Y. Cell. Mol. Life Sci. (2012) 69: 2635. doi:10.1007/s00018-012-0942-4

Abstract

Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside.

Keywords

Myocardial repairTissue engineeringTissue regenerationHeart tissueCardiac tissueHeart repairHeart regeneration

Abbreviations

CABG

Coronary artery bypass graft

ESC

Embryonic stem cells

HSC

Hematopoietic stem cells

hESC-CM

Human embryonic stem cell-derived cardiomyocytes

iPSC

Induced pluripotent stem cells

Isl-1

Islet 1 transcription factor

LAD

Left anterior descending

LVAD

Left ventricular assist device

LVEDV

Left ventricular end-diastolic volume

LVEF

Left ventricular ejection fraction

MI

Myocardial infarct

PCL

Poly ε-caprolactone

PGA

Polyglycolic acid

PIPAAm

Poly(N-isopropylacrylamide)

PLA

Polylactic acid

Sca-1

Stem cell antigen 1

Tbx18

T-box transcription factor 18

TB4

Thymosin-β4

TMRM

Tetramethylrhodamine methyl ester perchlorate

Wt1

Wilm’s tumor 1

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Andre Alcon
    • 1
  • Esra Cagavi Bozkulak
    • 2
  • Yibing Qyang
    • 2
  1. 1.Yale University School of MedicineYale UniversityNew HavenUSA
  2. 2.Section of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale Stem Cell Center, Yale School of MedicineYale UniversityNew HavenUSA