Cellular and Molecular Life Sciences

, Volume 69, Issue 15, pp 2469–2483

Cytoskeleton responses in wound repair

  • Maria Teresa Abreu-Blanco
  • James J. Watts
  • Jeffrey M. Verboon
  • Susan M. Parkhurst
Review

DOI: 10.1007/s00018-012-0928-2

Cite this article as:
Abreu-Blanco, M.T., Watts, J.J., Verboon, J.M. et al. Cell. Mol. Life Sci. (2012) 69: 2469. doi:10.1007/s00018-012-0928-2

Abstract

Wound repair on the cellular and multicellular levels is essential to the survival of complex organisms. In order to avoid further damage, prevent infection, and restore normal function, cells and tissues must rapidly seal and remodel the wounded area. The cytoskeleton is an important component of wound repair in that it is needed for actomyosin contraction, recruitment of repair machineries, and cell migration. Recent use of model systems and high-resolution microscopy has provided new insight into molecular aspects of the cytoskeletal response during wound repair. Here we discuss the role of the cytoskeleton in single-cell, embryonic, and adult repair, as well as the striking resemblance of these processes to normal developmental events and many diseases.

Keywords

Wound repairSingle cellsMulticellularCytoskeletonActinMyosinPurse stringAdherens junctions

Abbreviations

ERM

Ezrin-radixin-moesin

SBMS

Spectrin-based membrane skeleton

ECM

Extracellular matrix

αSMA

Alpha smooth muscle actin

Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Maria Teresa Abreu-Blanco
    • 1
  • James J. Watts
    • 1
  • Jeffrey M. Verboon
    • 1
  • Susan M. Parkhurst
    • 1
  1. 1.Division of Basic SciencesFred Hutchinson Cancer Research CenterSeattleUSA