Cellular and Molecular Life Sciences

, Volume 69, Issue 12, pp 1917–1929

Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm

Authors

  • Jayapal Manikandan
    • Department of Physiology, Yong Loo Lin School of MedicineNational University of Singapore
    • Center of Excellence in Genomic Medicine Research (CEGMR), King Fahad Medical Research CenterKing AbdulAziz University
  • Narasimhan Kothandaraman
    • Center of Excellence in Genomic Medicine Research (CEGMR), King Fahad Medical Research CenterKing AbdulAziz University
    • Department of Physiology, Yong Loo Lin School of MedicineNational University of Singapore
    • Tembusu College, University Town
    • Center of Excellence in Genomic Medicine Research (CEGMR), King Fahad Medical Research CenterKing AbdulAziz University
    • Institute of Immunity, Infection and Inflammation, College of Medicine, Veterinary and Life Sciences, 120 Glasgow Biomedical Research CentreUniversity of Glasgow
Review

DOI: 10.1007/s00018-011-0886-0

Cite this article as:
Manikandan, J., Kothandaraman, N., Hande, M.P. et al. Cell. Mol. Life Sci. (2012) 69: 1917. doi:10.1007/s00018-011-0886-0

Abstract

Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.

Keywords

AllergyAnaphylaxisFcεRIIgECytokinesTranscriptionFactorsFunctionalGenomics

Copyright information

© Springer Basel AG 2011