Cellular and Molecular Life Sciences

, Volume 69, Issue 9, pp 1415–1423

Regulation of neutrophil trafficking from the bone marrow


DOI: 10.1007/s00018-011-0870-8

Cite this article as:
Day, R.B. & Link, D.C. Cell. Mol. Life Sci. (2012) 69: 1415. doi:10.1007/s00018-011-0870-8


Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil homeostasis in the blood is highly regulated. Neutrophil number in the blood is determined by the balance between neutrophil production in the bone marrow and release from the bone marrow to blood with neutrophil clearance from the circulation. This review will focus on mechanisms regulating neutrophil release from the bone marrow. In particular, recent data demonstrating a central role for the chemokines CXCL12 and CXCL2 in regulating neutrophil egress from the bone marrow will be discussed.


NeutrophilsGranulocyte colony-stimulating factor (G-CSF)CXCR4CXCR2CXCL12 (stromal derived factor-1; SDF-1)CXCL1CXCL2Leukocyte traffickingWHIM syndrome

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© Springer Basel AG 2011

Authors and Affiliations

  1. 1.Division of Oncology, Department of Internal MedicineWashington University School of MedicineSaint LouisUSA