Review

Cellular and Molecular Life Sciences

, Volume 69, Issue 9, pp 1415-1423

First online:

Regulation of neutrophil trafficking from the bone marrow

  • Ryan B. DayAffiliated withDivision of Oncology, Department of Internal Medicine, Washington University School of Medicine
  • , Daniel C. LinkAffiliated withDivision of Oncology, Department of Internal Medicine, Washington University School of Medicine Email author 

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Abstract

Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil homeostasis in the blood is highly regulated. Neutrophil number in the blood is determined by the balance between neutrophil production in the bone marrow and release from the bone marrow to blood with neutrophil clearance from the circulation. This review will focus on mechanisms regulating neutrophil release from the bone marrow. In particular, recent data demonstrating a central role for the chemokines CXCL12 and CXCL2 in regulating neutrophil egress from the bone marrow will be discussed.

Keywords

Neutrophils Granulocyte colony-stimulating factor (G-CSF) CXCR4 CXCR2 CXCL12 (stromal derived factor-1; SDF-1) CXCL1 CXCL2 Leukocyte trafficking WHIM syndrome