Cellular and Molecular Life Sciences

, Volume 69, Issue 8, pp 1211–1259

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1

  • Bin Xue
  • Marcin J. Mizianty
  • Lukasz Kurgan
  • Vladimir N. Uversky
Review

DOI: 10.1007/s00018-011-0859-3

Cite this article as:
Xue, B., Mizianty, M.J., Kurgan, L. et al. Cell. Mol. Life Sci. (2012) 69: 1211. doi:10.1007/s00018-011-0859-3

Abstract

Many proteins and protein regions are disordered in their native, biologically active states. These proteins/regions are abundant in different organisms and carry out important biological functions that complement the functional repertoire of ordered proteins. Viruses, with their highly compact genomes, small proteomes, and high adaptability for fast change in their biological and physical environment utilize many of the advantages of intrinsic disorder. In fact, viral proteins are generally rich in intrinsic disorder, and intrinsically disordered regions are commonly used by viruses to invade the host organisms, to hijack various host systems, and to help viruses in accommodation to their hostile habitats and to manage their economic usage of genetic material. In this review, we focus on the structural peculiarities of HIV-1 proteins, on the abundance of intrinsic disorder in viral proteins, and on the role of intrinsic disorder in their functions.

Keywords

HIV-1Viral proteinProtein–protein interactionIntrinsically disordered proteinMoRF

Supplementary material

18_2011_859_MOESM1_ESM.docx (71 kb)
Supplementary material 1 (DOCX 70 kb)

Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • Bin Xue
    • 1
  • Marcin J. Mizianty
    • 2
  • Lukasz Kurgan
    • 2
  • Vladimir N. Uversky
    • 1
    • 3
  1. 1.Department of Molecular MedicineUniversity of South Florida, College of MedicineTampaUSA
  2. 2.Department of Electrical and Computer EngineeringUniversity of AlbertaEdmontonCanada
  3. 3.Institute for Biological Instrumentation, Russian Academy of SciencesPushchinoRussia