, Volume 68, Issue 21, pp 3495-3503
Date: 24 Aug 2011

Transcriptional control of natural killer cell differentiation and function

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Abstract

Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in interdependent networks, guide development and eventually generate specific phenotypes. Transcription factors (TF) are a key element in the regulatory cascade controlling cell fate and effector functions. In this review, we discuss recent data on the diversity of TF that determine natural killer (NK) cell fate and NK cell function.