What’s the hype about CDK5RAP2?
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Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might lead to disease in humans when the function of this protein is disturbed.
- What’s the hype about CDK5RAP2?
Cellular and Molecular Life Sciences
Volume 68, Issue 10 , pp 1719-1736
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- Online ISSN
- SP Birkhäuser Verlag Basel
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- Cell cycle
- Mental retardation
- Industry Sectors
- Author Affiliations
- 1. Department of Pediatric Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
- 2. Institute of Neuroanatomy and Cell Biology, Center for Anatomy, Charité, Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany
- 3. Center for Neuroscience, Indian Institute of Science, Bangalore, 560 012, India
- 4. Institute of Neuroanatomy and Cell Biology and Department of Pediatric Neurology, Charité, Universitätsmedizin Berlin, Center for Anatomy, Charité, Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany