Review

Cellular and Molecular Life Sciences

, Volume 68, Issue 12, pp 2003-2012

From axon–glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase

  • Eva-Maria Krämer-AlbersAffiliated withMolecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz Email author 
  • , Robin WhiteAffiliated withInstitute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University Email author 

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Abstract

Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon–glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon–glia interaction mediating myelination.

Keywords

Axon–glia interaction Src family kinase Myelin L1-CAM Translational control hnRNP-A2 Integrin Contactin