Cellular and Molecular Life Sciences

, Volume 68, Issue 6, pp 951–964

Biology of FGFRL1, the fifth fibroblast growth factor receptor

Review

DOI: 10.1007/s00018-010-0576-3

Cite this article as:
Trueb, B. Cell. Mol. Life Sci. (2011) 68: 951. doi:10.1007/s00018-010-0576-3

Abstract

FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead contains a short intracellular tail with a peculiar histidine-rich motif. The gene for FGFRL1 is found in all metazoans from sea anemone to mammals. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell differentiation. Mice with a targeted deletion of the Fgfrl1 gene die perinatally due to alterations in their diaphragm. These mice also show bilateral kidney agenesis, suggesting an essential role for Fgfrl1 in kidney development. A human patient with a frameshift mutation exhibits craniosynostosis, arguing for an additional role of FGFRL1 during bone formation. FGFRL1 contributes to the complexity of the FGF signaling system.

Keywords

Fibroblast growth factor (FGF)Fibroblast growth factor receptor (FGFR)FGFRL1HeparinKidney developmentBone formation

Abbreviations

FGF

Fibroblast growth factor

FGFR

Fibroblast growth factor receptor

Ig-like

Immunoglobulin-like

ITIM

Immunoreceptor tyrosine-based inhibition motif

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  1. 1.Department of Clinical ResearchUniversity of BernBernSwitzerland