Cellular and Molecular Life Sciences

, Volume 67, Issue 24, pp 4185–4196

Translating tissue-engineered tracheal replacement from bench to bedside

  • Madhuri Kalathur
  • Silvia Baiguera
  • Paolo Macchiarini
Review

DOI: 10.1007/s00018-010-0499-z

Cite this article as:
Kalathur, M., Baiguera, S. & Macchiarini, P. Cell. Mol. Life Sci. (2010) 67: 4185. doi:10.1007/s00018-010-0499-z

Abstract

There are a variety of airway diseases with different clinical settings, which may extend from a surgical approach to total organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissue in the body and seems to be a promising approach for airway replacement. The successful implantation of stem-cell-based tissue-engineered trachea in a young woman with end-stage post-tuberculosis left main bronchus collapse serves as a prototype for the airway tissue-engineered-based approach. The trachea indeed could represent a perfect model system to investigate the translational aspects of tissue engineering, largely due to its low-oxygen needs. This review highlights the anatomy of the airways, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.

Keywords

DecellularizationIn situ tissue engineeringMesenchymal stem cellsRegenerative medicineTissue engineeringTracheaTransplantation

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Madhuri Kalathur
    • 1
  • Silvia Baiguera
    • 1
  • Paolo Macchiarini
    • 1
  1. 1.BIOAIR Lab, Department of General Thoracic and Regenerative Surgery and Intrathoracic BiotransplantationUniversity Hospital CareggiFlorenceItaly