Non-canonical activation of Notch signaling/target genes in vertebrates
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- Sanalkumar, R., Dhanesh, S.B. & James, J. Cell. Mol. Life Sci. (2010) 67: 2957. doi:10.1007/s00018-010-0391-x
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Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.