Cellular and Molecular Life Sciences

, Volume 67, Issue 17, pp 2957–2968

Non-canonical activation of Notch signaling/target genes in vertebrates

  • Rajendran Sanalkumar
  • Sivadasan Bindu Dhanesh
  • Jackson James
Review

DOI: 10.1007/s00018-010-0391-x

Cite this article as:
Sanalkumar, R., Dhanesh, S.B. & James, J. Cell. Mol. Life Sci. (2010) 67: 2957. doi:10.1007/s00018-010-0391-x

Abstract

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

Keywords

Notch signaling CBF1-independent Notch Hes-1 Non-canonical Notch Neural differentiation Tumorigenesis 

Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Rajendran Sanalkumar
    • 1
  • Sivadasan Bindu Dhanesh
    • 1
  • Jackson James
    • 1
  1. 1.Neuro-Stem Cell Biology Laboratory, Neurobiology DivisionRajiv Gandhi Centre for BiotechnologyThiruvananthapuramIndia