Review

Cellular and Molecular Life Sciences

, Volume 67, Issue 17, pp 2897-2908

Post-transcriptional global regulation by CsrA in bacteria

  • Johan TimmermansAffiliated withLaboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles
  • , Laurence Van MelderenAffiliated withLaboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles Email author 

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Abstract

Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.

Keywords

CsrB CsrC Central carbon metabolism Motility Biofilm formation