Review

Cellular and Molecular Life Sciences

, Volume 67, Issue 16, pp 2773-2786

First online:

Dengue virus life cycle: viral and host factors modulating infectivity

  • Izabela A. Rodenhuis-ZybertAffiliated withMolecular Virology Section, Department of Medical Microbiology, University Medical Center Groningen, University of Groningen
  • , Jan WilschutAffiliated withMolecular Virology Section, Department of Medical Microbiology, University Medical Center Groningen, University of Groningen
  • , Jolanda M. SmitAffiliated withMolecular Virology Section, Department of Medical Microbiology, University Medical Center Groningen, University of Groningen Email author 

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Abstract

Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50–100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.

Keywords

Dengue Flavivirus Life cycle Immune response Pathogenesis Host factors Virulence Antibody-dependent enhancement