Cellular and Molecular Life Sciences

, 66:553

Chronic granulomatous disease

Visions & Reflections (Minireview)

DOI: 10.1007/s00018-009-8506-y

Cite this article as:
Segal, B.H., Romani, L. & Puccetti, P. Cell. Mol. Life Sci. (2009) 66: 553. doi:10.1007/s00018-009-8506-y


Chronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses, which in turn restrains fungal growth and calibrates the inflammatory response to minimize injury and allergy. In this model, superoxide-induced activation of indoleamine 2,3-dioxygenase (IDO) is a central mechanism by which the optimal balance of antifungal host defense and immune tolerance occurs. This model is based on studies in mice and requires correlation in humans.


Chronic granulomatous diseaseNADPH oxidaseinflammationInterleukin-17indoleamine 2,3-dioxygenase

Copyright information

© Birkhäuser Verlag, Basel 2009

Authors and Affiliations

  1. 1.Departments of Medicine and Immunology, Division of Infectious DiseasesRoswell Park Cancer InstituteBuffaloUSA
  2. 2.Department of Experimental MedicineUniversity of PerugiaPerugiaItaly