Cellular and Molecular Life Sciences

, Volume 66, Issue 22, pp 3615–3623

The response of human skeletal muscle tissue to hypoxia

Multi-author Review

DOI: 10.1007/s00018-009-0146-8

Cite this article as:
Lundby, C., Calbet, J.A.L. & Robach, P. Cell. Mol. Life Sci. (2009) 66: 3615. doi:10.1007/s00018-009-0146-8


Hypoxia refers to environmental or clinical settings that potentially threaten tissue oxygen homeostasis. One unique aspect of skeletal muscle is that, in addition to hypoxia, oxygen balance in this tissue may be further compromised when exercise is superimposed on hypoxia. This review focuses on the cellular and molecular responses of human skeletal muscle to acute and chronic hypoxia, with emphasis on physical exercise and training. Based on published work, it is suggested that hypoxia does not appear to promote angiogenesis or to greatly alter oxidative enzymes in skeletal muscle at rest. Although the HIF-1 pathway in skeletal muscle is still poorly documented, emerging evidence suggests that muscle HIF-1 signaling is only activated to a minor degree by hypoxia. On the other hand, combining hypoxia with exercise appears to improve some aspects of muscle O2 transport and/or metabolism.



Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Carsten Lundby
    • 1
    • 2
  • Jose A. L. Calbet
    • 3
  • Paul Robach
    • 4
  1. 1.The Copenhagen Muscle Research CentreCopenhagenDenmark
  2. 2.Department of Sport ScienceUniversity of ÅrhusÅrhus NDenmark
  3. 3.Department of Physical EducationUniversity of Las Palmas de Gran CanariaLas Palmas de Gran CanariaSpain
  4. 4.Ecole Nationale de Ski et d’AlpinismeChamonixFrance