Cellular and Molecular Life Sciences

, Volume 66, Issue 18, pp 3067–3080

Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells

  • Gusheng Tang
  • Qin Qin
  • Peng Zhang
  • Guifang Wang
  • Menglei Liu
  • Qingli Ding
  • Yanghua Qin
  • Qian Shen
Research Article

DOI: 10.1007/s00018-009-0090-7

Cite this article as:
Tang, G., Qin, Q., Zhang, P. et al. Cell. Mol. Life Sci. (2009) 66: 3067. doi:10.1007/s00018-009-0090-7

Abstract

A costimulatory signal from an inducible costimulator (ICOS) of T cells plays a critical role in immunological homeostasis. This study shows that the interaction of ICOSIg and its ligand (ICOSL) on mouse bone marrow-derived dendritic cells (DCs) induces a p38-MAPK dependent elevation of interleukin 6 (IL-6). It also enhances phagocytosis and the antigen-presentation function of DCs in vitro, further favoring cell-mediated immunity in vivo. As seen for other types of costimulator molecules expressed in the T cells in the CD28 family, it is shown here for the first time that ICOS can also deliver reverse signals through its ligand to ICOSL-expressing cells. These reverse signals in turn transfer positive immunogenic information to bone marrow-derived DCs. Our work therefore provides new recognition of an ICOSL/ICOS signal pathway in immunity and also supplies more evidence that this ICOSL/ICOS signal pathway is a reasonable target for therapeutic drugs.

Keywords

Inducible costimulator Reverse signal Dendritic cells Interleukin-6 p38-MAPK Immunological homeostasis 

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Gusheng Tang
    • 1
  • Qin Qin
    • 1
  • Peng Zhang
    • 1
  • Guifang Wang
    • 2
  • Menglei Liu
    • 1
  • Qingli Ding
    • 1
  • Yanghua Qin
    • 1
  • Qian Shen
    • 1
  1. 1.Department of Laboratory Diagnosis, Changhai HospitalThe Second Military Medical UniversityShanghaiChina
  2. 2.Department of Respiratory Medicine, Changzheng HospitalThe Second Military Medical UniversityShanghaiChina

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