Cellular and Molecular Life Sciences

, Volume 66, Issue 19, pp 3149–3160

Faithful after break-up: suppression of chromosomal translocations

Authors

    • Department of Molecular Medicine, Institute of BiotechnologyUniversity of Texas Health Science Center at San Antonio
    • Genome Instability Section, Genetics and Molecular Biology BranchNational Human Genome Research Institute, National Institutes of Health
Review

DOI: 10.1007/s00018-009-0068-5

Cite this article as:
Lee, S.E. & Myung, K. Cell. Mol. Life Sci. (2009) 66: 3149. doi:10.1007/s00018-009-0068-5

Abstract

Chromosome integrity in response to chemically or radiation-induced chromosome breaks and the perturbation of ongoing replication forks relies on multiple DNA repair mechanisms. However, repair of these lesions may lead to unwanted chromosome rearrangement if not properly executed or regulated. As these types of chromosomal alterations threaten the cell’s and the organism’s very own survival, multiple systems are developed to avoid or at least limit break-induced chromosomal rearrangements. In this review, we highlight cellular strategies for repressing DNA break-induced chromosomal translocations in multiple model systems including yeast, mouse, and human. These pathways select proper homologous templates or broken DNA ends for the faithful repair of DNA breaks to avoid undesirable chromosomal translocations.

Keywords

Chromosomal translocationDouble strand breakDNA repairHomologous recombinationEnd joining

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009