Cellular and Molecular Life Sciences

, Volume 66, Issue 15, pp 2427–2443

Intracellular protein degradation in mammalian cells: recent developments

Authors

    • Centro de Investigación Príncipe Felipe
    • Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII
  • Carmen Aguado
    • Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII
  • Jaime Cárcel
    • Centro de Investigación Príncipe Felipe
  • Inmaculada Esteban
    • Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII
  • Juan Miguel Esteve
    • Centro de Investigación Príncipe Felipe
  • Ghita Ghislat
    • Centro de Investigación Príncipe Felipe
  • José Félix Moruno
    • Centro de Investigación Príncipe Felipe
  • José Manuel Vidal
    • Centro de Investigación Príncipe Felipe
  • Rosana Sáez
    • Departamento de Biología CelularUniversidad de Valencia
Review

DOI: 10.1007/s00018-009-0030-6

Cite this article as:
Knecht, E., Aguado, C., Cárcel, J. et al. Cell. Mol. Life Sci. (2009) 66: 2427. doi:10.1007/s00018-009-0030-6

Abstract

In higher organisms, dietary proteins are broken down into amino acids within the digestive tract but outside the cells, which incorporate the resulting amino acids into their metabolism. However, under certain conditions, an organism loses more nitrogen than is assimilated in the diet. This additional loss was found in the past century to come from intracellular proteins and started an intensive research that produced an enormous expansion of the field and a dispersed literature. Therefore, our purpose is to provide an updated summary of the current knowledge on the proteolytic machinery involved in intracellular protein degradation and its physiological and pathological relevance, especially addressed to newcomers in the field who may find further details in more specialized reviews. However, even providing a general overview, this is an extremely wide field and, therefore, we mainly focus on mammalian cells, while other cells will be mentioned only for comparison purposes.

Keywords

Intracellular protein degradationProteasesProteasomesUbiquitinLysosomesAutophagyCell injury

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009