Cellular and Molecular Life Sciences

, Volume 66, Issue 14, pp 2275–2283

The effect of photodynamic therapy on tumor angiogenesis

  • Ramaswamy Bhuvaneswari
  • Yik Yuen Gan
  • Khee Chee Soo
  • Malini Olivo
Review

DOI: 10.1007/s00018-009-0016-4

Cite this article as:
Bhuvaneswari, R., Gan, Y.Y., Soo, K.C. et al. Cell. Mol. Life Sci. (2009) 66: 2275. doi:10.1007/s00018-009-0016-4

Abstract

Photodynamic therapy (PDT), the activation of a photosensitive drug in tumor tissue with light of specific wavelength, has been used effectively to treat certain solid tumors. Though therapeutic responses are encouraging, PDT-mediated oxidative stress can act as an angiogenic switch that ultimately leads to neovascularization and tumor recurrence. This article explores the effect of PDT on angiogenesis in different tumor models. Overexpression of proangiogenic vascular endothelial growth factor, cyclooxygenase-2 and matrix metalloproteases has often been reported post-illumination. Recent clinical studies have demonstrated that inhibiting angiogenesis after chemotherapy and radiotherapy is an attractive and valuable approach to cancer treatment. In this review, we report the effective therapeutic strategy of combining angiogenesis inhibitors with PDT to control and treat tumors.

Keywords

AngiogenesisPhotodynamic therapy (PDT)CancerVascular endothelial growth factor (VEGF)Cyclooxygenase-2 (COX-2)Angiogenic inhibitors

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Ramaswamy Bhuvaneswari
    • 1
  • Yik Yuen Gan
    • 2
  • Khee Chee Soo
    • 1
  • Malini Olivo
    • 1
    • 3
    • 4
  1. 1.National Cancer Centre SingaporeSingaporeSingapore
  2. 2.Natural Sciences and Science Education, National Institute of EducationNanyang Technological UniversitySingaporeSingapore
  3. 3.Singapore Bioimaging ConsortiumBiomedical Sciences InstitutesSingaporeSingapore
  4. 4.Department of PharmacyNational University of SingaporeSingaporeSingapore