Cellular and Molecular Life Sciences

, Volume 66, Issue 13, pp 2123–2134

Recent advances in understanding the structure and function of general transcription factor TFIID

Authors

  • Emilie Cler
    • Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULP
  • Gabor Papai
    • Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULP
  • Patrick Schultz
    • Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULP
    • Institut de Génétique et de Biologie Moléculaire et CellulaireCNRS/INSERM/ULP
Review

DOI: 10.1007/s00018-009-0009-3

Cite this article as:
Cler, E., Papai, G., Schultz, P. et al. Cell. Mol. Life Sci. (2009) 66: 2123. doi:10.1007/s00018-009-0009-3
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Abstract

The general transcription factor TFIID is a macromolecular complex comprising the TATA-binding protein (TBP) and a set of 13–14 TBP associated factors (TAFs). This review discusses biochemical, genetic and electron microscopic data acquired over the past years that provide a model for the composition, organisation and assembly of TFIID. We also revisit ideas on how TFIID is recruited to the promoters of active and possibly repressed genes. Recent observations show that recognition of acetylated and methylated histone residues by structural domains in several TAFs plays an important role. Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state.

Keywords

DrosophilaYeastElectron microscopyChromatinAcetylationMethylation

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009