Cellular and Molecular Life Sciences

, 66:370

Rac1 GTPase: A “Rac” of All Trades

Visions and Reflections (Minireview)

DOI: 10.1007/s00018-008-8552-x

Cite this article as:
Bosco, E.E., Mulloy, J.C. & Zheng, Y. Cell. Mol. Life Sci. (2009) 66: 370. doi:10.1007/s00018-008-8552-x


Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.


Rac1Rho GTPasesproliferationcytoskeletonsurvival

Copyright information

© Birkhäuser Verlag, Basel 2008

Authors and Affiliations

  1. 1.Division of Experimental Hematology and Cancer BiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA