Cellular and Molecular Life Sciences

, Volume 66, Issue 5, pp 814–830

Death Effector Domain-Containing Proteins


DOI: 10.1007/s00018-008-8489-0

Cite this article as:
Valmiki, M.G. & Ramos, J.W. Cell. Mol. Life Sci. (2009) 66: 814. doi:10.1007/s00018-008-8489-0


Death effector domains (DEDs) are protein-protein interaction structures that are found in proteins that regulate a variety of signal transduction pathways. DEDs are a part of the larger family of Death Domain structures that have been primarily described in the control of programmed cell death. The seven standard DED-containing proteins are fas associated death domain protein (FADD), Caspase-8 and 10, cellular FLICE-like inhibitory protein (c-FLIP), death effector domain containing DNA binding (DEDD), DEDD2 and phosphoprotein enriched in astrocytes 15-Kda (PEA-15). These proteins are particularly associated with the regulation of apoptosis and proliferation mediated by the tumor necrosis factor α (TNFα) receptor family. Consequently DED-containing proteins are reported to regulate transcription, migration, and proliferation, in addition to both pro and anti-apoptotic functions. Moreover, DED proteins are essential in embryonic development and homeostasis of the immune system. Here we focus on the role of DED-containing proteins in development and the pathologies arising from abnormal expression of these proteins.


Death effector domainapoptosisproliferationsignal transductionmigrationcaspaseFADD

Copyright information

© Birkhäuser Verlag, Basel 2008

Authors and Affiliations

  1. 1.Department of Molecular Biosciences and BioengineeringUniversity of Hawaii at ManoaHonoluluUSA
  2. 2.Department of Natural Products and Cancer Biology, Cancer Research Center of HawaiiUniversity of Hawaii at ManoaHonoluluUSA