Cellular and Molecular Life Sciences

, Volume 66, Issue 5, pp 773–787

The role of the ZEB family of transcription factors in development and disease

Authors

  • C. Vandewalle
    • Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical ResearchGhent University
    • Department of Molecular BiologyGhent University
  • F. Van Roy
    • Department of Molecular BiologyGhent University
    • Molecular Cell Biology Unit, Department for Molecular Biomedical ResearchVIB, Ghent University
    • Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical ResearchGhent University
    • Department of Molecular BiologyGhent University
Review

DOI: 10.1007/s00018-008-8465-8

Cite this article as:
Vandewalle, C., Van Roy, F. & Berx, G. Cell. Mol. Life Sci. (2009) 66: 773. doi:10.1007/s00018-008-8465-8

Abstract.

The ZEB family of zinc finger transcription factors are essential players during normal embryonic development. One characteristic is that they induce epithelial to mesenchymal transition (EMT), a process that reorganizes epithelial cells to become migratory mesenchymal cells. E-cadherin is a major target gene of these transcriptional repressors, and this downregulation is considered a hallmark of EMT. In recent years, the involvement of the ZEB proteins in pathological contexts has been documented as well. Mutations in ZEB encoding genes cause severe syndromic malformations and evidence is mounting that links these factors to malignant tumor progression. In this review, we describe what is currently known on the molecular pathways these transcription factors are implicated in, and we highlight their roles in development and human diseases, with a focus on tumor malignancy.

Keywords.

EMTZEBdevelopmentcancerinvasiontranscriptionmigration

Copyright information

© Birkhäuser Verlag, Basel 2008