Cellular and Molecular Life Sciences

, 65:4000

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

  • D. M. Taylor
  • M. M. Maxwell
  • R. Luthi-Carter
  • A. G. Kazantsev
Review

DOI: 10.1007/s00018-008-8357-y

Cite this article as:
Taylor, D.M., Maxwell, M.M., Luthi-Carter, R. et al. Cell. Mol. Life Sci. (2008) 65: 4000. doi:10.1007/s00018-008-8357-y

Abstract.

Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and organismal processes, including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in less than a decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development. Here, we present a review of published results on sirtuin biology and its relevance to human disease.

Keywords.

Sirtuindeacetylaselongevityhuman diseasetherapeutics

Copyright information

© Birkhäuser Verlag, Basel 2008

Authors and Affiliations

  • D. M. Taylor
    • 1
  • M. M. Maxwell
    • 2
  • R. Luthi-Carter
    • 1
  • A. G. Kazantsev
    • 2
  1. 1.Brain Mind InstituteEcole Polytechnique Fédérale de Lausanne (EPFL)LausanneSwitzerland
  2. 2.Mass General Institute for Neurodegenerative DiseaseMassachusetts General Hospital and Harvard Medical SchoolCharlestownUSA