Cellular and Molecular Life Sciences

, Volume 65, Issue 18, pp 2842–2858

Membrane traffic in the secretory pathway

Endosome protein sorting: motifs and machinery

Authors

    • Cambridge Institute for Medical Research/Dept. of Clinical BiochemistryUniversity of Cambridge
Multi-author Review

DOI: 10.1007/s00018-008-8354-1

Cite this article as:
Seaman, M.N.J. Cell. Mol. Life Sci. (2008) 65: 2842. doi:10.1007/s00018-008-8354-1

Abstract.

The steady-state localisation of membrane proteins in the endocytic system is the result of many sorting events that occur at various points throughout the endosomal pathway. A protein that has been endocytosed from the plasma membrane or sorted at the trans-Golgi network (TGN) and transported to an endosome will ultimately be delivered to one of three destinations: the plasma membrane, the TGN or the lysosome. Where a membrane protein is trafficked to depends on the interactions between sorting motifs present in the membrane protein and the machinery that can decode these motifs. Much of the protein machinery that recognises sorting motifs is conserved from yeast toman, and in this review I will discuss this machinery and the motifs that govern endosomal protein sorting. (Part of a Multi-author Review)

Keywords.

Sortingcoat proteinsmotifsendosomevesicletubule

Copyright information

© Birkhaueser 2008