Cellular and Molecular Life Sciences

, Volume 65, Issue 23, pp 3789–3808

Proliferating cell nuclear antigen: a proteomics view

Authors

    • Tumour Biology GroupNortheastern Ontario Regional Cancer Program at the Sudbury Regional Hospital
Review

DOI: 10.1007/s00018-008-8305-x

Cite this article as:
Naryzhny, S.N. Cell. Mol. Life Sci. (2008) 65: 3789. doi:10.1007/s00018-008-8305-x

Abstract.

Proliferating cell nuclear antigen (PCNA), a cell cycle marker protein, is well known as a DNA sliding clamp for DNA polymerase delta and as an essential component for eukaryotic chromosomal DNA replication and repair. Due to its mobility inside nuclei, PCNA is dynamically presented in a soluble or chromatin-associated form. The heterogeneity and specific modifications of PCNA may reflect its multiple functions and the presence of many binding partners in the cell. The recent proteomics approaches applied to characterizing PCNA interactions revealed multiple PCNA partners with a wide spectrum of activity and unveiled the possible existence of new PCNA functions. Since more than 100 PCNA-interacting proteins and several PCNA modifications have already been reported, a proteomics point of view seems exactly suitable to better understand the role of PCNA in cellular functions.

Keywords.

Proliferating cell nuclear antigenproteomicsinteractionfunctions
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Copyright information

© Birkhäuser Verlag, Basel 2008