REGγ, a proteasome activator and beyond?
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REGγ, a member of the 11S proteasome activators, has been shown to bind and activate the 20S proteasome to promote proteasome-dependent degradation of important regulatory proteins, such as SRC-3 and cyclin-dependent kinase inhibitors p21, p16, and p19, in a ubiquitin- and ATP-independent manner. Furthermore, REGγ has been shown to facilitate the turnover of tumor suppressor p53 by promoting MDM2-mediated p53 ubiquitination. The discovery that REGγ regulates cell-cycle regulators is consistent with previous studies where REGγ-deficient mice have shown retardation in body growth, decreased cell proliferation and increased apoptosis, indicating a potential role of REGγ in cancer development. Additionally, REGγ’s ability to promote viral protein degradation suggests its involvement in viral pathogenesis. This review presents an overview of the function of REGγ, a summary of the current literature, and insight into the possible biological function of REGγ relating to cancer, viral pathogenesis, and other diseases.
- REGγ, a proteasome activator and beyond?
Cellular and Molecular Life Sciences
Volume 65, Issue 24 , pp 3971-3980
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- Proteasome activator
- ubiquitin- and ATP-independent protein degradation
- viral pathogenesis
- Industry Sectors
- Author Affiliations
- 1. The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Experimental Building B-519, 500 Dongchuan Rd., Shanghai, 200241, China
- 2. The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Providence Heart + Lung Institute, St. Paul’s Hospital, Vancouver, BC, V6Z 1Y6, Canada