Visions & Reflections (Minireview)

Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 2953-2956

First online:

Protein assemblies with palindromic structure motifs

  • N. PinotsisAffiliated withEMBL HamburgSection of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories
  • , M. WilmannsAffiliated withEMBL Hamburg Email author 

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Abstract.

Symmetric DNA sequence motifs allow the formation of palindromic protein/DNA complexes. Although symmetric protein sequence motifs are less common, recent structural discoveries have unraveled a few protein/protein complexes with palindromic symmetry. Remarkably, symmetric protein/protein complexes can be generated either by adjacent or remote sequence motifs, which may be repeated or inverted. This contribution reflects and comments on recent findings of palindromic protein/protein complexes.

Keywords.

Protein structure palindromic symmetry SH3 domain titin muscle