Cellular and Molecular Life Sciences

, Volume 65, Issue 19, pp 2953–2956

Protein assemblies with palindromic structure motifs


  • N. Pinotsis
    • EMBL Hamburg
    • Section of Structural BiologyInstitute of Cancer Research, Chester Beatty Laboratories
    • EMBL Hamburg
Visions & Reflections (Minireview)

DOI: 10.1007/s00018-008-8265-1

Cite this article as:
Pinotsis, N. & Wilmanns, M. Cell. Mol. Life Sci. (2008) 65: 2953. doi:10.1007/s00018-008-8265-1


Symmetric DNA sequence motifs allow the formation of palindromic protein/DNA complexes. Although symmetric protein sequence motifs are less common, recent structural discoveries have unraveled a few protein/protein complexes with palindromic symmetry. Remarkably, symmetric protein/protein complexes can be generated either by adjacent or remote sequence motifs, which may be repeated or inverted. This contribution reflects and comments on recent findings of palindromic protein/protein complexes.


Protein structurepalindromic symmetrySH3 domaintitinmuscle

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© Birkhaueser 2008