, Volume 65, Issue 18, pp 2913-2923
Date: 19 Aug 2008

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

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Abstract.

Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

Received 13 May 2008; received after revision 07 July 2008; accepted 11 July 2008