Cellular and Molecular Life Sciences

, Volume 65, Issue 18, pp 2913–2923

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors


DOI: 10.1007/s00018-008-8263-3

Cite this article as:
Bellone, C., Lüscher, C. & Mameli, M. Cell. Mol. Life Sci. (2008) 65: 2913. doi:10.1007/s00018-008-8263-3


Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.


Long-term depressionsynaptic transmissionmetabotropic glutamate receptorsAMPA receptors

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Dept. of Basic Neurosciences, Medical FacultyUniversity of GenevaGenevaSwitzerland
  2. 2.Clinic of Neurology, Dept. of Clinical NeurosciencesGeneva University HospitalGenevaSwitzerland