Cellular and Molecular Life Sciences

, Volume 65, Issue 18, pp 2924–2932

Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway

  • M. Tang
  • M. Zhong
  • Y. Shang
  • H. Lin
  • J. Deng
  • H. Jiang
  • H. Lu
  • Y. Zhang
  • W. Zhang
Research Article

DOI: 10.1007/s00018-008-8255-3

Cite this article as:
Tang, M., Zhong, M., Shang, Y. et al. Cell. Mol. Life Sci. (2008) 65: 2924. doi:10.1007/s00018-008-8255-3

Abstract.

Advanced glycation end products (AGEs) play an important role in collagen deposition in diabetic cardiomyopathy. TRB3, a mammalian homolog of Drosophila tribbles, functions to increase glucose intolerance and regulates cell proliferation. We demonstrated that AGEs induce collagen type I expression but inhibit collagen type III expression, accompanied by increased TRB3 expression. Furthermore, the collagen type I induced byAGEs was down-regulated after inhibition of ERK and p38-MAPK, the collagen type III reduced by AGEs was up-regulated after inhibition of ERK. The expression of collagen types I and III regulated by AGEs through MAPK was partly reversed after treatment with TRB3 siRNA. It suggests that the TRB3/MAPK signaling pathway participates in the regulation of collagen types I and III by AGEs and may provide new therapeutic strategies for diabetic cardiomyopathy.

Keywords.

Advanced glycation end products cardiac fibroblasts collagen tribble 3 mitogen-activated protein kinase 

Supplementary material

18_2008_8255_MOESM1_ESM.pdf (292 kb)
(PDF 293 kb)
18_2008_8255_MOESM2_ESM.pdf (296 kb)
(PDF 297 kb)

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  • M. Tang
    • 1
    • 2
  • M. Zhong
    • 2
    • 3
  • Y. Shang
    • 2
  • H. Lin
    • 4
  • J. Deng
    • 5
  • H. Jiang
    • 2
  • H. Lu
    • 2
    • 3
  • Y. Zhang
    • 2
    • 3
  • W. Zhang
    • 2
    • 3
  1. 1.Department of Emergency MedicineQilu Hospital of Shandong UniversityJinanP. R. China
  2. 2.Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of Education and Public HealthJinanP. R. China
  3. 3.Department of CardiologyQilu Hospital of Shandong UniversityJinanP. R. China
  4. 4.The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouP. R. China
  5. 5.Department of AnatomyShandong UniversityJinanP. R. China