Review

Cellular and Molecular Life Sciences

, Volume 65, Issue 16, pp 2528-2540

First online:

Purinergic regulation of neutrophil chemotaxis

  • W. G. JungerAffiliated withDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School Email author 

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Abstract.

Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage.

Keywords.

Neutrophils inflammation chemotaxis puringeric receptors tissue damage