Cellular and Molecular Life Sciences

, Volume 65, Issue 15, pp 2385–2396

Biological Roles of Neural J Proteins

Review

DOI: 10.1007/s00018-008-8089-z

Cite this article as:
Zhao, X., Braun, A.P. & Braun, J.E.A. Cell. Mol. Life Sci. (2008) 65: 2385. doi:10.1007/s00018-008-8089-z

Abstract.

J proteins are chief regulators of the Hsp70 family, a highly conserved family of ATPases that mediate conformational changes in a broad range of proteins. The J protein family has been the central focus of numerous prokaryote and eukaryote biologists. Common questions that arise include: How does the J protein/Hsp70 machinery support protein folding? What role do J proteins play in protein misfolding and neurodegenerative disorders? Can the J protein/ Hsp70 machinery be harnessed to provide a rational basis for recombinant protein production? The current progress that has resulted from the convergence of biochemistry with Escherichia coli and Saccharomyces cerevisiae genetics has accelerated the pace at which these questions are being elucidated. We are beginning to gain some insights into the neuronal network of J proteins. Here, we highlight recent advances in our understanding of how select J proteins harness Hsp70 s for fundamentally important conformational work in neurons.

Keywords.

J proteins Hsp70 s chaperones auxilin GAK CSPα Rdj2 Rme-8 Hsp40 Mrj Hsj1 

Copyright information

© Birkhaueser 2008

Authors and Affiliations

  1. 1.Hotchkiss Brain Institute, Department of Physiology and BiophysicsThe University of CalgaryCalgaryCanada
  2. 2.Libin Cardiovascular Institute of Alberta, Department of Pharmacology and TherapeuticsUniversity of CalgaryCalgaryCanada

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