, Volume 65, Issue 14, pp 2191-2214
Date: 19 May 2008

G protein βγ subunits: Central mediators of G protein-coupled receptor signaling

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G protein βγ subunits are central participants in G protein-coupled receptor signaling pathways. They interact with receptors, G protein α subunits and downstream targets to coordinate multiple, different GPCR functions. Much is known about the biology of Gβγ subunits but mysteries remain. Here, we will review what is known about general aspects of structure and function of Gβγ as well as discuss emerging mechanisms for regulation of Gβγ signaling. Recent data suggest that Gβγ is a potential therapeutic drug target. Thus, a thorough understanding of the molecular and physiological functions of Gβγ has significant implications.

Received 04 January 2008; received after revision 04 February 2008; accepted 27 February 2008