Cellular and Molecular Life Sciences

, Volume 65, Issue 11, pp 1698-1705

First online:

Cbln and C1q family proteins – New transneuronal cytokines

  • M. YuzakiAffiliated withDepartment of Neurophysiology, School of Medicine, Keio University Email author 

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The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2–Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.


Cerebellin cerebellum synapse formation synaptic plasticity tumor necrosis factor Purkinje cell granule cell