Cellular and Molecular Life Sciences

, Volume 65, Issue 6, pp 862–894

Endoplasmic reticulum stress responses

Authors

    • School of Biological and Biomedical SciencesDurham University
Review

DOI: 10.1007/s00018-007-7383-5

Cite this article as:
Schröder, M. Cell. Mol. Life Sci. (2008) 65: 862. doi:10.1007/s00018-007-7383-5

Abstract.

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis causes stress. In this review I summarize how perturbation of three major functions of the endoplasmic reticulum (ER) in eukaryotic cells–protein folding, lipid and sterol biosynthesis, and storing intracellular Ca2+ – causes ER stress and activates signaling pathways collectively termed the unfolded protein response (UPR). I discuss how the UPR reestablishes homeostasis, and summarize our current understanding of how the transition from protective to apoptotic UPR signaling is controlled, and how the UPR induces inflammatory signaling.

Keywords.

ApoptosisCa2+ storecholesterolendoplasmic reticulummembrane fluiditymolecular chaperoneprotein foldingunfolded protein response

Copyright information

© Birkhaueser 2007