Cellular and Molecular Life Sciences

, 64:2459

Lipid sensing and lipid sensors

Peroxisome Proliferator-Activated Receptors as sensors of fatty acids and derivatives
Multi-author Review

DOI: 10.1007/s00018-007-7278-5

Cite this article as:
Grimaldi, P.A. Cell. Mol. Life Sci. (2007) 64: 2459. doi:10.1007/s00018-007-7278-5


Lipid homeostasis requires a strict balance between lipid intake and consumption. This balance is controlled by different systems that regulate food intake, energy storage and energy expenditure. This review focuses on the roles of peroxisome proliferator- activated receptors (PPARs) in some of these regulatory processes. PPARs are transcription factors that bind and are activated by fatty acids and fatty acid derivatives. They act as lipid sensors and adapt the metabolism and development of various tissues to lipid availability. Due to their actions on lipid metabolism, PPARs are bona fide therapeutic targets in the treatment of metabolic syndrome not only by affecting gene expression patterns in several tissues but also by inducing remodeling of tissues such as adipose or skeletal muscle.


PPARfatty acidobesitytype 2 diabetesmetabolic syndrome

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Inserm U636, Centre de Biochimie, UFR SciencesUniversité de Nice-Sophia AntipolisNiceFrance