Cellular and Molecular Life Sciences

, Volume 64, Issue 18, pp 2391–2403

Towards progress on DNA vaccines for cancer

  • D. B. Lowe
  • M. H. Shearer
  • C. A. Jumper
  • R. C. Kennedy
Review

DOI: 10.1007/s00018-007-7165-0

Cite this article as:
Lowe, D.B., Shearer, M.H., Jumper, C.A. et al. Cell. Mol. Life Sci. (2007) 64: 2391. doi:10.1007/s00018-007-7165-0

Abstract.

Cancer immunotherapy faces many obstacles that include eliciting immune reactions to self antigens as well as overcoming tumor-derived immunosuppressive networks and evasion tactics. Within the vaccine arsenal for inhibiting cancer proliferation, plasmid DNA represents a novel immunization strategy that is capable of eliciting both humoral and cellular arms of the immune response in addition to being safely administered and easily engineered and manufactured. Unfortunately, while DNA vaccines have performed well in preventing and treating malignancies in animal models, their overall application in human clinical trials has not impacted cancer regression to date. Since the establishment of these early trials, progress has been made in terms of increasing DNA vaccine immunogenicity and subverting the suppressive properties of tumor cells. Therefore, the success of future plasmid DNA use in cancer patients will depend on combinatorial strategies that enhance and direct the DNA vaccine immune response while also targeting tumor evasion mechanisms.

Keywords.

DNA vaccinescancerimmunotherapynon-human primatesanimal models

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • D. B. Lowe
    • 1
  • M. H. Shearer
    • 1
  • C. A. Jumper
    • 1
    • 2
    • 3
  • R. C. Kennedy
    • 1
    • 3
  1. 1.Department of Microbiology and ImmunologyTexas Tech University Health Sciences CenterLubbockUSA
  2. 2.Internal MedicineTexas Tech University Health Sciences CenterLubbockUSA
  3. 3.Southwest Cancer Treatment and Research CenterLubbockUSA