Cellular and Molecular Life Sciences

, Volume 64, Issue 17, pp 2270–2284

The metabolism and function of sphingolipids and glycosphingolipids


DOI: 10.1007/s00018-007-7076-0

Cite this article as:
Lahiri, S. & Futerman, A.H. Cell. Mol. Life Sci. (2007) 64: 2270. doi:10.1007/s00018-007-7076-0


Sphingolipids and glycosphingolipids are emerging as major players in many facets of cell physiology and pathophysiology. We now present an overview of sphingolipid biochemistry and physiology, followed by a brief presentation of recent advances in translational research related to sphingolipids. In discussing sphingolipid biochemistry, we focus on the structure of sphingolipids, and their biosynthetic pathways – the recent identification of most of the enzymes in this pathway has led to significant advances and better characterization of a number of the biosynthetic steps, and the relationship between them. We then discuss some roles of sphingolipids in cell physiology, particularly those of ceramide and sphingosine-1-phosphate, and mention current views about how these lipids act in signal transduction pathways. We end with a discussion of sphingolipids and glycosphingolipids in the etiology and pathology of a number of diseases, such as cancer, immunity, cystic fibrosis, emphysema, diabetes, and sepsis, areas in which sphingolipids are beginning to take a central position, even though many of the details remain to be elucidated.



Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  1. 1.Department of Biological ChemistryWeizmann Institute of ScienceRehovotIsrael