Cellular and Molecular Life Sciences

, Volume 64, Issue 14, pp 1841–1852

Aminoglycoside antibiotics: old drugs and new therapeutic approaches

Authors

    • Department of Chemistry and BiochemistryUniversity of California San Diego
Biomedicine & Diseases: Review

DOI: 10.1007/s00018-007-7034-x

Cite this article as:
Hermann, T. Cell. Mol. Life Sci. (2007) 64: 1841. doi:10.1007/s00018-007-7034-x

Abstract.

Aminoglycoside antibiotics kill bacteria by binding to the ribosomal decoding site and reducing fidelity of protein synthesis. Since the discovery of these natural products over 50 years ago, aminoglycosides have provided a mainstay of antibacterial therapy of serious Gram-negative infections. In recent years, aminoglycosides have become important tools to study molecular recognition of ribonucleic acid (RNA). In an ingenious exploitation of the aminoglycosides’ mechanism of action, it has been speculated that drug-induced readthrough of premature stop codons in mutated messenger RNAs might be used to treat patients suffering from certain heritable genetic disorders.

Keywords.

Aminoglycoside antibioticscystic fibrosisdrug discoverymuscular dystrophyribosomeRNA

Copyright information

© Birkhäuser Verlag, Basel 2007