Cellular and Molecular Life Sciences

, 64:674

Cardiovascular development: towards biomedical applicability

Biology of Isl1+ cardiac progenitor cells in development and disease

Authors

  • A. Moretti
    • Klinikum rechts der Isar - TechnischeUniversität München, I. Medizinische Klinik - Molekulare Kardiologie
  • J. Lam
    • Klinikum rechts der Isar - TechnischeUniversität München, I. Medizinische Klinik - Molekulare Kardiologie
    • Skaggs School of PharmacyUniversity of California, San Diego, School of Medicine
    • Klinikum rechts der Isar - TechnischeUniversität München, I. Medizinische Klinik - Molekulare Kardiologie
Multi-author Review

DOI: 10.1007/s00018-007-6520-5

Cite this article as:
Moretti, A., Lam, J., Evans, S.M. et al. Cell. Mol. Life Sci. (2007) 64: 674. doi:10.1007/s00018-007-6520-5

Abstract.

The LIM-homeodomain transcription factor Islet-1 (Isl1) marks a cell population which makes a substantial contribution to the embryonic heart. Isl1 expression is downregulated as soon as the cells adopt a differentiated phenotype, suggesting that this transcription factor delineates a cardiogenic progenitor cell population. Taking advantage of this developmental lineage marker, we have identified in the postnatal heart a novel cardiac cell type, which is capable of self-renewal and readily differentiates into mature cardiomyocytes. Utilization of embryonic stem (ES) cells that harbour knock-ins of reporter genes into the endogenous Isl1 locus will enable us to isolate Isl1+ cardiac progenitors from mouse and human ES cell systems during in vitro cardiogenesis. These genetic cell-based systems should allow the direct identification of signalling pathways which guide formation, renewal and diversification of Isl1+ cardiogenic progenitors into distinct heart cell lineages, and would complement in vitro studies in the mouse embryo during cardiac development.

Keywords.

Cardiac developmentembryonic stem cellsisl1+ cardiac progenitorssecond heart fieldheart lineages
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Copyright information

© Birkhäuser Verlag, Basel 2007