Cellular and Molecular Life Sciences

, 64:661

Cardiovascular development: towards biomedical applicability

Resident cardiac stem cells

Authors

  • D. Torella
    • Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical MedicineMagna Graecia University
    • Laboratory of Molecular and Cellular Physiology, The Research Institute for Sport & Exercise SciencesLiverpool John Moores University
  • G. M. Ellison
    • Laboratory of Molecular and Cellular Physiology, The Research Institute for Sport & Exercise SciencesLiverpool John Moores University
    • Cardiovascular Institute and Center for Cardiovascular HealthMount Sinai School of Medicine
  • I. Karakikes
    • Cardiovascular Institute and Center for Cardiovascular HealthMount Sinai School of Medicine
    • Cardiovascular Institute and Center for Cardiovascular HealthMount Sinai School of Medicine
Multi-author Review

DOI: 10.1007/s00018-007-6519-y

Cite this article as:
Torella, D., Ellison, G.M., Karakikes, I. et al. Cell. Mol. Life Sci. (2007) 64: 661. doi:10.1007/s00018-007-6519-y

Abstract.

Regardless of erroneous claims by a minority of reports, adult cardiomyocytes are terminally differentiated cells which do not re-enter the cell-cycle under any known physiological or pathological circumstances. However, it has recently been shown that the adult heart has a robust myocardial regenerative potential, which challenges the accepted notions of cardiac cellular biology. The source of this regenerative potential is constituted by resident cardiac stem cells (CSCs). These CSCs, through both cell transplantation and in situ activation, have the capacity to regenerate significant segmental and diffuse myocyte losts, restoring anatomical integrity and ventricular function. Thus, CSC identification has started a brand new discipline of cardiac biology that could profoundly changed the outlook of cardiac physiology and the potential for treatment of cardiac failure. Nonetheless, the dawn of this new era should not be set back by premature attempts at clinical application before having accumulated the required scientifically reproducible data.

Keywords.

Cardiac stem cellsmyocardial regenerationstem cell plasticitystem cell nichestem cell fate

Copyright information

© Birkhäuser Verlag, Basel 2007