Visions & Reflections (Minireview)

Cellular and Molecular Life Sciences

, Volume 64, Issue 11, pp 1323-1328

First online:

Ruminations on dietary restriction and aging

  • B. K. KennedyAffiliated withDepartment of Biochemistry, University of Washington Email author 
  • , K. K. SteffenAffiliated withDepartment of Biochemistry, University of Washington
  • , M. KaeberleinAffiliated withDepartment of Pathology, University of Washington Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Calorie restriction has been known for many decades to extend the life span of rodents. Since the more recent discovery that a long-term reduction in nutrient intake also extends life span in nearly every invertebrate model organism used for aging research, the mechanisms behind the longevity benefits of this intervention have been under intense scrutiny. While models have been developed in yeast, worms, and flies, the molecular mechanisms governing life span extension by calorie restriction remain controversial, resulting in great anticipation of mammalian studies testing these models. Here we discuss the links between nutrient reduction and enhanced longevity with emphasis on evolutionarily conserved nutrient response signaling.


Aging calorie restriction dietary restriction nutrient sensing TOR kinase insulin PKA