Cellular and Molecular Life Sciences

, Volume 64, Issue 2, pp 131–138

Telomeres and meiosis in health and disease

Regulation of telomere movement by telomere chromatin structure
  • T. K. Pandita
  • C. R. Hunt
  • G. G. Sharma
  • Q. Yang
Multi-author Review

DOI: 10.1007/s00018-006-6465-0

Cite this article as:
Pandita, T.K., Hunt, C.R., Sharma, G.G. et al. Cell. Mol. Life Sci. (2007) 64: 131. doi:10.1007/s00018-006-6465-0

Abstract.

Beyond their role in replication and chromosome end capping, telomeres are also thought to function in meiotic chromosome pairing, meiotic and mitotic chromosome segregation as well as in nuclear organization. Observations in both somatic and meiotic cells suggest that the positioning of telomeres within the nucleus is highly specific and believed to be dependent mainly on telomere interactions with the nuclear envelope either directly or through chromatin interacting proteins. Although little is known about the mechanism of telomere clustering, some studies show that it is an active process. Recent data have suggested a regulatory role for telomere chromatin structure in telomere movement. This review will summarize recent studies on telomere interactions with the nuclear matrix, telomere chromatin structure and factors that modify telomere chromatin structure as related to regulation of telomere movement.

Keywords.

Telomere chromatin structuretelomere binding factorsATMtelomere nuclear matrix interactionstelomere movement

Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • T. K. Pandita
    • 1
  • C. R. Hunt
    • 1
  • G. G. Sharma
    • 1
  • Q. Yang
    • 1
  1. 1.Department of Radiation OncologyWashington University School of MedicineSt. LouisUSA